Rapid and sensitive assays for the identification of plant pathogens are necessary for the effective management of crop diseases.The main limitation of current diagnostic testing is the inability to combine broad and sensitive pathogen detection with the identification of key strains, pathovars, and subspecies.Such discrimination is necessary for q
Defining information fractions in group sequential clinical trials with multiple endpoints
The group sequential design Landscape Lighting has been well understood and widely applied in designs of late phase clinical trial to enable potentially early stopping for efficacy or futility.The information fraction (IF) is one of the key elements to determine the decision boundary at the interim analyses.The family-wise error rate (FWER) control